The Expressions of PDGF-C, PDGF-D and PDGF Receptors in Renal Development Model / 대한신장학회잡지
Korean Journal of Nephrology
; : 170-180, 2005.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-58660
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Four platelet derived growth factor (PDGF) family members have been identified; the classical PDGFs, PDGF-A and PDGF-B, and the novel PDGFs, PDGF-C and PDGF-D, which were only recently discovered.METHODS:
The present study was designed to determine the changes of the platelet derived growth factor (PDGF) subtypes (C & D) and their receptors (PDGFR)-alpha & beta expression in kidneys during pre- and postnatal development.RESULTS:
All the protein levels of PDGFR-alpha and -beta and the mRNA levels of PDGF-C and D were high in kidneys during the prenatal period and decreased differently during the postnatal period. PDGFR-alpha was expressed in the interstitial space at embryo day 18. PDGFR-beta protein were expressed in metanephric blastema at embryo day 18. PDGF-C mRNA was expressed in metanephric blastema, developing glomerulus at embryo 18 day and in collecting duct at postnatal day 7. PDGF-D mRNA was expressed in the parietal and vesceral epithelial cells during pre and postnatal period.CONCLUSION:
These results indicate that the PDGF subtypes (C & D) and their receptors (PDGFR-alpha & -beta) are differently expressed in the kidney during the prenatal and postnatal period.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator de Crescimento Derivado de Plaquetas
/
RNA Mensageiro
/
Receptores do Fator de Crescimento Derivado de Plaquetas
/
Estruturas Embrionárias
/
Células Epiteliais
/
Rabeprazol
/
Rim
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Ano de publicação:
2005
Tipo de documento:
Artigo