Improved technology of inducing dilated cardiomyopathy animal model of rats by peritoneally injecting adriamycin / 基础医学与临床

ABSTRACT

Objective To develop rats model for human dilated cardiomyopathy(DCM).Methods Male Sprague-Dawley rats were administered adriamycin intraperitoneally 2.8 mg/kg? week)for 11 weeks,and then observed for 2 weeks.Plasma levels of brain natriuretic peptide(BNP)were studied by ELISA;left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)were measured by echocardiogram;and morphology of the hearts and pathological lesions of cardiac muscle tissues were observed.Results(1)The levels of BNP of the DCM group were higher than those of the normal group(P