Plasma ghrelin levels in women with polycystic ovary syndrome and in hyperandrogenic women / 医学研究生学报

ABSTRACT

Objective:(i)to compare plasma ghrelin levels between women with PCOS and women presented only with hyperandrogenaemia;(ii)to investigate the relationship between circulating ghrelin and BMI、insulin level,insulin resistance,and Androgen levels in PCOS.Methods:Blood samples from sixty women with PCOS,15 women with only hyperandrogenaemia and 40 controls were collected,the basal levels of gonadotrophin,androgens,prolactin,sex hormone-binding globulin,glucose,insulin and ghrelin were measured.Results:(1)Comparing with PCOS and Controls,women with only hyperandrogenaemia had the lowest ghrelin levels;women with PCOS had lower ghrelin levels comparing with controls,but they were not significant.(2)Ghrelin levels were negatively correlated with BMI、WHR、Insulin levels and Insulin Resistance,positively correlated with sex hormone-binding globulin levels.Conclusion:In PCOS,circulating ghrelin and BMI、Insulin Resistance、SHBG levels were inversely related,indicating that Ghrelin might be associated with energy balance,obesity,and Insulin Resistance.However,further investigation was needed to clarify whether low ghrelin was a cause or the consequence of obesity and Insulin Resistance awaits.