Effects of Gastrodin on BDNF Expression in AD Tree Shrew / 昆明医科大学学报
Journal of Kunming Medical University
; (12): 29-30,37, 2013.
Article
em Zh
| WPRIM
| ID: wpr-598644
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the effect of gastrodin on brain-derived neurotrophic factor (BDNF) expression in Alzheimer's disease ( AD) tree shrew. Methods AD tree shrew model was established by intracerebroventricular injection with amyloid-βpeptide (Aβ) . Since the eighth day after injection, the tree shrews were treated with gastrodin for thirty days. The expression of BDNF in tree threw hippocampus was detected by reverse transcription polymerase chain reaction (RT-PCR) . Results The expression of BDNF mRNA in the treatment group was higher than that in the model group ( <0.05) . Conclusion Gastrodin can increase some degree of the expression of BDNF.
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1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Kunming Medical University
Ano de publicação:
2013
Tipo de documento:
Article