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Effect of simulated 400 m He-O2 saturation diving on oxidative-antioxidative system in lungs of rats / 军事医学
Military Medical Sciences ; (12): 493-494,498, 2014.
Article em Zh | WPRIM | ID: wpr-599583
Biblioteca responsável: WPRO
ABSTRACT
Objective To investigate the effect of simulated 400 m He-O2 saturation diving on the pulmonary oxidative-antioxidative system in rats.Methods SD rats were exposed to 4.1 MPa He-O2 mixture for 24 h in an animal chamber. Normal air pressure was used in the control group .The histopathology , contents of malondialdehyde ( MDA) , 8-hydroxy-2′-deoxyguanosine(8-OHdG),and glutathione(GSH) and activities of superoxide dismutase (SOD) and glutathione peroxi-dase( GSH-Px) in pulmonary tissues were determined .Results No difference was found during pathological examination or in MDA, 8-OHdG and SOD activity.GSH and GSH-Px activity were decreased significantly (P<0.05) after hyperbaric exposure.Conclusion Exposure to 4.1 MPa He-O2 for 24 h may promote oxidative stress and reduce antioxidative capacity rather than cause obvious oxidative damage in rat lungs .
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Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Military Medical Sciences Ano de publicação: 2014 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Revista: Military Medical Sciences Ano de publicação: 2014 Tipo de documento: Article