Research progress on curcuma zedoary extracts inhibiting vascular smooth muscle cell proliferation in pathological process of in-stent restenosis / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 19-21,22, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-603147
Biblioteca responsável:
WPRO
ABSTRACT
Vascular smooth muscle cells (VSMCs) proliferation is the critical pathological process of in-stent restenosis (ISR). Recent researches indicate that the traditional Chinese medicine curcuma zedoary (E’zhu) can inhibit VSMCs proliferation, with a potential value in preventing and treating ISR. The major ac-tive components of curcuma zedoary are curcuma and β-elemene. The underlying mechanisms involve the inhibition of hemeoxygen-ase-1 expression, blockade of extracellular signal-regulated ki-nase – MAPK and Akt pathways, and subsequent cell cycle ar-rest. This article reviews the recent progress on curcuma zedoary extracts regulating VSMCs proliferation in ISR.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2016
Tipo de documento:
Artigo