High-dose methotrexate and L-asparaginase for the treatment of adult patients with high risk Ph-acute lymphoblastic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 740-742,745, 2015.
Article
em Zh
| WPRIM
| ID: wpr-603800
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the efficacy and safety of high-dose methotrexate (MTX) and L-asparaginase (L-Asp) for the treatment of adult patients with high risk Ph acute lymphoblastic leukemia (ALL).Methods Five adult patients with high risk Ph-ALL were treated with several courses of MTX (3-5 g/m2 by continually intravenous drip for 24 h) and L-Asp (8 000-10 000 U/time, once a day, 10 times for one cycle).Results Five patients were disease-free survival, their survival time was 60-96 months and the median survival time was 73 months.The chemotherapy-related bone marrow depression was mild.No obvious liver and kidney damage, severe allergic reaction and pancreatitis were observed.Conclusion Highdose MTX and L-Asp are effective and well tolerated, and may contribute to long-term survival of adult patients with high risk Ph-ALL.
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1
Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
Idioma:
Zh
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2015
Tipo de documento:
Article