Preparation of Paeonol-HP-β-cyclodextrin Inclusion Compound and Its Prescription Technology Optimiza-tion / 中国药房
China Pharmacy
; (12): 530-532,533, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-606074
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To prepare paeonol-HP-β-cyclodextrin (PAE-HP-β-CD) inclusion compound and to optimize its pre-scription technology.METHODS:
PAE-HP-β-CD was prepared by freeze drying method and validated. Using inclusion rate as in-dex,main drug-accessory ratio,inclusion time,inclusion temperature and stirring speed as factors,the preparation technology was optimized by central composite design-response surface methodology.RESULTS:
Prepared PAE-HP-β-CD underwent phase transfor-mation. The optimal inclusion technology was as follows as main drug-accessory ratio of 3.39∶1,inclusion temperature of 50 ℃, inclusion time of 3.2 h, stirring speed of 350 r/min. Relative error between measured value (87.46%) and predicted value (89.12%) of inclusion rate was 1.86%(n=6).CONCLUSIONS:
PAE-HP-β-CD inclusion compound is prepared successfully, and its prescription technology is stable and feasible.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo