Three Cases of Opsoclonus

ABSTRACT

Opsoclonus introduced in 1913, by Orzechowski is a disorder of eye movements charactenzed by involuntary bursts of multidirectional saccades without an intersaccadic Interval and persistulg during sleep, is often accompained by myoclonic jerks of the face and body. It is a rare condition, the common causes of which are viral encephalitides and a paraneoplastic manifestation of an occult malignant neoplasm The sites of the responsible lesion, however, hez been a matter of controversy; cerebellum midbrain, thalamus, thalamus and midbrain, has been suggested, as well as a combination of several sites in the central nervous system We present three cases of opsoclonus with brief review of literatures. The first and second case, suspected vural infection, presented with prodromal symptoms(fever, headache, sore throat), ataxia and opsoclonus. Clinical manifestations improved with clonazepam therapy, Tbe thlrd case is 9 month old male presented with vomiting, inguinal hernia, opsoclonus and poor nutrition. The brain CT scan revealed tumor at pons and midbrain.