Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1 / 现代检验医学杂志
Journal of Modern Laboratory Medicine
; (4): 162-164, 2017.
Article
em Zh
| WPRIM
| ID: wpr-613486
Biblioteca responsável:
WPRO
ABSTRACT
High mobility group box 1 protein,a kind of damage-associated molecular patterns,is a group of nonhistone DNA-binding protein in the nuclear.It not only involves in DNA replication,recombination,repair,regulation of gene transcription,but also induces activation of innate immunity and T cell generation and activates the adaptive immune response through Toll-like receptor.It is also more closely related to autoimmune diseases,inflammatory diseases,tumors and so on.Currently there are many researches on the role of TLR-mediated HMGB1 signaling pathway in diseases,which is involved in a variety of pathological processes and has a broad clinical outlook.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Modern Laboratory Medicine
Ano de publicação:
2017
Tipo de documento:
Article