Effect of Xiang-Qi-Tang on coagulation factors in mice with endotoxemia / 中国兽医学报
Chinese Journal of Veterinary Science
; (12): 1583-1588, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-615364
Biblioteca responsável:
WPRO
ABSTRACT
To study the anticoagulant effect of Xiang-Qi-Tang (XQT),the mice model of endotoxemia was established to detect the expression of coagulation factors and their regulatory proteins in serum and aorta.The results showed that XQT could decrease the expression of TF and increase the expression of tPA in the aorta of mice with endotoxemia,and also decrease the expression of sEPCR in the serum.We further found that XQT caused the decrease of sEPCR through the regulation of PKC δ and ADAM17 to contribute the anticoagulation in mice.This study may provide a new strategy for treating endotoxin-induced disease and provide evidences for further researching the pharmacological action of XQT.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Veterinary Science
Ano de publicação:
2017
Tipo de documento:
Artigo