Expression of microtubule-associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 532-538, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-618371
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To determine whether microtubule-associated protein 2 (MAP2) and microtubule-associated protein 1B (MAP1B) could be prognostic biomarkers for patients with pancreatic neuroendocrine tumors (PNETs).Methods:
With immunohisto-chemical staining, the expressions of MAP2 and MAP1B were examined in 193 and 120 primary tumors and peritumoral tissues, re-spectively. Then, the relationship between the expression of each protein and clinicopathological characteristics, including prognosis was analyzed.Results:
MAP2 and MAP1B were expressed in 88 of 193 (45.6%) and 77 of 120 (64.2%) tumors, respectively. The expres-sion of MAP2 was significantly associated with the favorable overall survival of patients with PNETs (P=0.012). Moreover, MAP2 expres-sion was associated with the improved overall survival in a subset of patients with stageⅡand stageⅢtumors (P=0.017). The MAP1B expression did not correlate with other clinicopathological features and prognosis.Conclusion:
MAP2 could be a novel, independent prognostcbiomarker for PNETs.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2017
Tipo de documento:
Artigo