Effects of Mifepristone on Related Indexes of Patients with Myomectomy / 中国药房

ABSTRACT

OBJECTIVE:To study the effects of mifepristone on related indexes of patients with myomectomy. METHODS:The information of 100 patients with uterine fibroids were analyzed retrospectively,and they were divided into observation group and control group according to therapy method,with 50 cases in each group. Control group only received myomectomy. Observa-tion group was given Mifepristone tablets 10 mg orally,qd,for consecutive 3 months,and then received myomectomy within 2 d after drug withdrawal;they were given Mifepristone tablets 10 mg/d orally after surgery,for consecutive 3 months. The 2 groups were followed up for 6 months. The maximual volume of uterine fibroids and the volume of uterus were compared between 2 groups as well as related operation indicator,levels of serun reproductive hormones,sex hormones of uterine myoma tissure and re-lated growth factors of uterus myomas. The recurrence and occurrence of ADR was recorded during treatment. RESULTS:Before surgery,the maximual volume of uterine fibroids and the volume of uterus in observation group were significantly lower than control group,with statistical significance(P0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Mife-pristone helps to reduce operative time,intraoperative blood loss,vaginal bleeding time and hospital stay of patients with myomecto-my,and may be related to the regulation of ER and PR levels and related growth factor receptors.