Association of rs10181656 Polymorphism in Signal Transducer and Activator of Transcription 4 Gene with Susceptibility to Unexplained Recurrent Spontaneous Abortion / 中山大学学报(医学科学版)
Journal of Sun Yat-sen University(Medical Sciences)
; (6): 551-555, 2017.
Article
em Zh
| WPRIM
| ID: wpr-621445
Biblioteca responsável:
WPRO
ABSTRACT
[Objective] To investigate associations between the functional polymorphisms of signal transducer and activator of transcription 4 (STAT4) gene and unexplained recurrent spontaneous abortion (URSA) and between STAT4 protein expression and the genotypes of rs 10181656 locus.[Methods] PCR-restriction fragment length polymorphism was used to genotype rs 1 0181656 locus polymorphism in 332 URSA cases and 260 normal controls,in 86 URSA cases and 77 normal controls of which immunohistochemical technique was used to detect STAT4 protein expression.[Results] The frequencies of rs10181656 C/G were 36.45 %,46.54% in genotype C/C,46.99%,45.38% in genotype C/G and 16.57%,8.08% in genotype G/G between URSA patients and normal controls.They reached statistical difference (P < 0.05).The carriers of rs 10181656 G allele increased the risk of URSA (OR =1.50,P < 0.05).STAT4 protein expression in decidual tissues:①There was statistical difference in the STAT4 protein expression in decidual tissues between cases and controls (P < 0.05).In URSA patients there was statistical difference in the STAT4 protein expression among genotype CC,CG and GG of rs10181656 locus (P < 0.05).So was in normal controls (P < 0.05).In genotype CC there was no difference in the STAT4 protein expression between cases and controls (P > 0.05).Neither was In genotype CG and GG respectively (P all > 0.05).[Conclusion] Functional polymorphisms of the rs10181656 locus could probably associate with the susceptibility of URSA via STAT4 protein expression increased by genotype G/G in maternal decidual tissue.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Sun Yat-sen University(Medical Sciences)
Ano de publicação:
2017
Tipo de documento:
Article