High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi / 감염과화학요법
Infection and Chemotherapy
; : 431-434, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-62686
Biblioteca responsável:
WPRO
ABSTRACT
We compared the infectivity and growth rates of 12 strains of Orientia tsutsugamushi in a cell culture system. ECV304 cells were infected with O. tsutsugamushi strains for 4 hr, and the culture was maintained for 72 hr. Immunofluorescence (IF) staining was performed at 4, 24, 48, and 72 hr after inoculation (hpi), and IF-positive foci were enumerated. The AFSC-4 strain, which is known to be insensitive to doxycycline, showed higher numbers of IF-positive foci than the other 11 strains at 4, 24, 48, and 72 hpi, which may explain its apparent insensitivity to antibiotics.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Orientia tsutsugamushi
/
Virulência
/
Resistência a Medicamentos
/
Tifo por Ácaros
/
Imunofluorescência
/
Doxiciclina
/
Técnicas de Cultura de Células
/
Antibacterianos
Idioma:
Inglês
Revista:
Infection and Chemotherapy
Ano de publicação:
2013
Tipo de documento:
Artigo