Pharmacogenomics screening of HLA-B*1502 in epilepsy patients: How we do it in the UKM Medical Centre, Malaysia
Neurology Asia
; : 27-29, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-628743
Biblioteca responsável:
WPRO
ABSTRACT
Previous studies have shown that carbamazepine-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) patients is associated with the HLA-B*1502 allele. Screening for HLA-B*1502 before using carbamazepine can prevent SJS/TEN particularly in populations with high frequency of the allele. The objective of this paper was to describe how the UKM Medical Centre, Malaysia was able to set up a cost effective screening of HLA-B*1502 for patients taking carbamazepine. The cost of in-house HLA-B⁄1502 screening was less than those commercially available, and was sensitive and specifi c.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Neurology Asia
Ano de publicação:
2013
Tipo de documento:
Artigo