A second - look hysteroscopy after treatment of genital tuberculosis in an amenorrheic woman

ABSTRACT

A 32 year old G2P1 (1011) presented with amenorrhea of 2 years duration. Both sister and grandfather were diagnosed with Pulmonary Tuberculosis 10 years ago and adequately treated for 9 months with quadruple anti-Koch`s medications. Patient presented with no sign nor symptoms highly suspicious for tuberculosis. Physical and Pelvic examinations, complete endocrinologic investigations, chest X-ray and transvaginal ultrasound all revealed normal results. Progesterone challenge test failed to elicit withdrawal bleeding. Hyteroscopy showed a globularly fibrotic endometrial cavity, while endometrial biopsy revealed chronic granulomatous inflammation with Langhan`s giant cell typical of genital tuberculosis. She was subsequently started on anti-Koch`s medications for 6 months, with prompt resumption of menses after treatment. Second-look hysteroscopy on readmission showed normal, healthy-looking endometrium with no areas of fibrosis. Repeat endomentrial biopsy revealed benign secretory phase endometrium, with absolutely no evidence of chronic granulomatous inflammation. This paper aimed to underscore the value of hysteroscopy as a vital tool in the work-up amenorrhea, and to demonstrate, using second look hysteroscopy, the efficacy of anti-tuberculosis treatment on the uterine cavity in an amenorrheic woman diagnosed with genital tuberculosis.