Animal and clinical trials on a prototype, pressure limited, time cycled Philippine ventilator (PhilVent)
Acta Medica Philippina
; : 4-9, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-632901
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To test the efficacy and safety of PhilVent, a pressure limited, time cycled, Philippine ventilator through animal and clinical studies. METHODS ANDRESULTS:
Animal study Term, newborn piglets (N=8) were intubated and alternately cycled to the PhilVent or to a pressure limited, time cycled, commercial ventilator (Sechrist) at peak inspiratory pressures of 10, 13 and 15 cm H20 and rates of 15, 20, 25 breaths per min and constant FiO2 (0.40) and positive end expiratory pressure (+4). Blood gases and adverse events (pneumothorax, sudden deterioration, death) were monitored. Results show no significant difference in blood gases on either machine at the various ventilator settings. No adverse events occurred. Clinical study Prospective, randomized, controlled trial of 90 preterm infants with respiratory distress, randomized either to PhilVent (N=45) or Sechrist (N=45). Ventilator settings were adjusted to achieve predetermined range of blood gases. Arterial blood gases and any adverse events e.g., pneumothorax, pulmonary hemorrhage were monitored. There were no clinically significant differences in the ventilator settings or blood gases of the infants on the PhilVent or Sechrist. No increase in adverse events were noted with the PhilVent.CONCLUSION:
In animal and clinical studies, the efficacy and safety of the PhilVent were comparable to the Sechrist. The PhilVent is an effective, alternative ventilator for the treatment of respiratory insufficiency in newborn infants.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Outras Doenças Respiratórias
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filipinas
/
Pneumotórax
/
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Insuficiência Respiratória
/
Gasometria
/
Recém-Nascido Prematuro
/
Ventiladores Mecânicos
/
Estudos Prospectivos
/
Respiração com Pressão Positiva
/
Equipamentos e Provisões
Tipo de estudo:
Estudo observacional
Limite:
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Acta Medica Philippina
Ano de publicação:
2010
Tipo de documento:
Artigo