Progress in the research on clinical features of Best vitelliform macular dystrophy and mutations in BEST1 gene / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 621-624, 2015.
Article
em Zh
| WPRIM
| ID: wpr-637258
Biblioteca responsável:
WPRO
ABSTRACT
Best vitelliform macular dystrophy ( BVMD ) is an autosomal dominant disease mostly caused by mutations in BEST1 gene. These mutations change the normal physiological functions of BEST1-encoded bestrophin-1 protein, and finally lead to a reduction of visual acuity. This review is composed of the following aspects: the structure and functions of BEST1 gene, the characteristics of the mutations, clinical features of BVMD, genotype-phenotype correlations as well as possible gene therapy. Our contribution serves for further research on BVMD and BEST1 gene.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
International Eye Science
Ano de publicação:
2015
Tipo de documento:
Article