Changes of Insulin-Like Growth Factor-1 in Mice with Viral Myocarditis and Their Protective Effects on Myocardium / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)1986.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-639031
Biblioteca responsável:
WPRO
ABSTRACT
Objective To determine the significance of change of insulin-like growth factor-1(IGF-1) and study the effect of IGF-1 on expression of Bcl-2 and Bax.Methods Male Balb/c mice were randomly divided into control group,coxsackie B3(CVB3) infection group(infection group),CVB3 infection with IGF-1 treated group.Animals were killed at d7,d14.The immunohistochemical studies and medical imagine analysis system were performed to evaluate the expression of Bcl-2 and Bax in myocardial tissue.Serum IGF-1 concentrations were assayed by radioimmunoassay(RIA).Results In infection group,the concentrations of IGF-1 were more decreased than that of control group and the expression of Bcl-2 reduced and Bax increased(P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Applied Clinical Pediatrics
Ano de publicação:
1986
Tipo de documento:
Artigo