Meta Analysis of Helicobacter Pylori Infection and Idiopathic Thrombocytopenic Purpura in Children / 实用儿科临床杂志

ABSTRACT

Objective To assess the relationship between Helicobacter pylori(Hp) infection and idiopathic thrombocytopenic purpura (ITP) in children.Methods All the published literatures of relationship between Hp infection and childhood ITP were searched by computer and manual search from 2000 to 2010 in the CNKI database,WANFANG database,Chongqing Vip database and Pubmed database.A comprehensive analysis of case control studies were used by Meta analysis and calculated the value of integrated OR and 95%CI.Results Thirty-five pertinent literatures were collected.After literature which study methods not fit the request were ruled out,there were 8 effective documents in all,including 6 Chinese literatures,and 2 English literatures.Meta analysis of OR value and 95%CI were 1.90(1.44-2.50),and Z value of combined effect of tests was 4.56 (P=0.000 01) in ITP group and control group.Meta analysis results of OR value and 95%CI were 0.74(0.49-1.13),and Z value of combined effect of the test was 1.38 (P=0.17) in acute ITP and chronic ITP group.Conclusions Hp infection is closely related with the incidence of ITP,but has nothing to do with the type of ITP.