Effect of ambroxol chloride on aquaporin-5 expression in lipopolysaccharide-smoking inducible rats / 上海第二医科大学学报
Article
em Zh
| WPRIM
| ID: wpr-640680
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the expression of aquaporin-5(AQP5) in lipo-polysaccharide(LPS)-cigarette smoking inducible SD rats,and the effect of ambroxol chloride(AMB)on its expression. Methods Twenty-one SD rats were randomly divided into three groups: AMB intervention group,model group(LPS-cigarette smoking induction group) and control group.TNF-? was determined from lung homogenate supernatant,bronchial alveolar lavage fluid(BALF) and serum by ELISA.The semi-quantitation of AQP5 transcription and expression were measured by in situ hybridization and immunohistochemistry,respectively. Results TNF-? from lung homogenate supernatant and BALF in model group was more than AMB intervention group and control group(P
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Shanghai Jiaotong University(Medical Science)
Ano de publicação:
2006
Tipo de documento:
Article