Inhibition effect of c-Met inhibitor on proliferation of lens epithelial cells / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 743-744, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-641737
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To observe the inhibition of c-Met inhibitor on proliferation of lens epithelial cells (LECs).METHODS:
Human's LECs were cultured and hepatocyte growth factor (HGF) and K252a were added to second passage of cells supplied with Dulbecco's modified eagle's medium (DMEM). MTT assay was used to examine the proliferation of LECs, and Western-blot was used to detect the expression change of Bcl-2 and Caspase-3.RESULTS:
The photodensity (A) of HGF (50nmol/L) + K252a (30nmol/L) was not significantly different from that of DMEM control (P>0.05). The expression of Bcl-2 and Caspase-3 were not significantly different from that in the control group.CONCLUSION:
K252a, the inhibitor of c-Met, can effectively inhibit the proliferation of LECs.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Eye Science
Ano de publicação:
2006
Tipo de documento:
Artigo