Relationship between TGF-?/Smads signal transduction and leukemic cells / 上海第二医科大学学报
Article
em Zh
| WPRIM
| ID: wpr-642155
Biblioteca responsável:
WPRO
ABSTRACT
Transforming growth factor-?(TGF-?) is a kind of multifunctional cytokine that regulates cell growth,differentiation,cellular senescence,apoptosis,wound healing and embryo development.As a tumor suppressor,deregulated or aberrant TGF-? signaling has been strongly implicated in human solid tumors,as well as in normal and malignant hematopoiesis.TGF? exerts an inhibitory role during the whole procedure of hematopoiesis.As a cell cycle inhibitor,it maintains cells in a quiescent state and can downregulate expression of hematopoiesis activators and oncoproteins.In malignant hematopoiesis,altered expression of coactivators or corepressors involve in TGF-?-induced transcriptional responses and loss/disruption of TGF-? target gene expression.Then malignant cells grow and differentiate abnormally.In acute promyelocytic leukemia,PML-RAR? may inhibit TGF-? signaling through inhibition of cPML and nPML.Degradation of PML-RAR? by ATRA restores this signaling pathway.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Shanghai Jiaotong University(Medical Science)
Ano de publicação:
2006
Tipo de documento:
Article