The study of nerve regeneration with infiltration of normal saline and nerve growth factor after vein graft to the resected sciatic nerve / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
; : 17-24, 2001.
Article
em Ko
| WPRIM
| ID: wpr-643656
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To compare the effect of nerve regeneration with infiltration of normal saline and nerve growth factor after vein graft to the resected sciatic nerve of rat. MATERIALS AND METHODS: Eighty Sprague-Dawley rats were divided into five experimental groups: orthotopic nerve graft as control group, inside-in vein graft with normal saline infiltration, inside-out vein graft with normal saline infiltration, inside-in vein graft with nerve growth factor infiltration and inside-out vein graft with nerve growth factor infiltration group. Animals of each group were sacrificed after electromyography at 2, 4, 8 and 12 weeks after operation. Also the light microscopy and transmission electron microscopy were performed to observe histologic change of grafted sites. RESULTS: This study demonstrates that autogenous vein graft serves as a conduit for nerve regeneration, and inside-out vein graft technique and nerve growth factor induce faster and more numerous axonal regeneration and earlier recovery of muscle power. CONCLUSION: Inside-out vein graft with nerve growth factor infiltration is supposed to be a promising technique to take the place of autogenous nerve graft.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Regeneração
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Nervo Isquiático
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Axônios
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Veias
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Ratos Sprague-Dawley
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Transplantes
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Fator de Crescimento Neural
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Microscopia Eletrônica de Transmissão
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Eletromiografia
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Microscopia
Limite:
Animals
Idioma:
Ko
Revista:
The Journal of the Korean Orthopaedic Association
Ano de publicação:
2001
Tipo de documento:
Article