The Effect of Rutin on the Melanogenesis and Nitric Oxide in UVB-irradiated HM3KO Human Melanoma / 대한해부학회지
Korean Journal of Anatomy
; : 49-56, 2003.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-645508
Biblioteca responsável:
WPRO
ABSTRACT
Ultraviolet (UV) radiation is the main physiological stimulus for human skin pigmentation. Recently, nitric oxide (NO) have been involved in mediation of skin pigmentation induced by UVB. Rutin, a flavonoid of vegetables and fruits, has antiviral and antioxidant properties. Therefore, we investigated the effect of rutin on UVB-induced melano-genesis and NO production in HM3KO cells. In this study, we demonstrated that UVB-irradiation stimulated melanin content and tyrosinase activity in HM3KO cells. Rutin suppressed UVB-stimulated total melanin content and tyrosinase activity in a dose-dependent manner. Additionally, we showed that UVB-irradiation stimulated NO production in HM3KO cells. Rutin also suppressed UVB-induced NO production and repaired reduction of cell proliferation by UVB. UVB stimulation of melanogenesis was mimicked by exogenous NO donor (sodium nitroprusside, SNP), and rutin effectively suppressed it. Therefore, we concluded that rutin suppressed UVB-stimulated melanogenesis and that it is involved in melanogenesis regulation partially through the suppression of UVB-induced NO production.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Rutina
/
Doadores de Tecidos
/
Verduras
/
Pigmentação da Pele
/
Nitroprussiato
/
Negociação
/
Monofenol Mono-Oxigenase
/
Proliferação de Células
/
Frutas
/
Melaninas
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Ano de publicação:
2003
Tipo de documento:
Artigo