The Prophylaxis of Venous Thromboembolism in Korean Patients with Total Knee Replacement Arthroplasty / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
; : 86-95, 2012.
Article
em Ko
| WPRIM
| ID: wpr-646398
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To evaluate the effects and problems of venous thromboembolism (VTE) prophylaxis with a reduced dosage and administration period in Korean total knee arthroplasty (TKA) patients. MATERIALS AND METHODS: We analyzed 135 consecutive TKA patients with three different VTE prophylaxis regimens. Group dalteparin-aspirin (DA) injected dalteparin for the first 2 days, followed by taking aspirin for the next 5 days, Group aspirin (A) was on aspirin and Group dalteparin (D) on dalteparin 7 days postoperatively. We evaluated the incidence of VTE and safety among the 3 groups. RESULTS: Symptomatic deep vein thrombosis was detected in 4 cases (Group DA: 2, Group A: 1, Group D: 1). Pulmonary embolism (PE) was found in 1 case in each group with no fatal PE. Although no major bleeding complications were seen, minor bleeding incidents were detected in 14 cases (Group DA: 2, Group A: 1, Group D: 11), which was significant in Group D. No significant differences were observed in perioperative blood loss, effusion in the knee joint, thigh swelling or oozing on the wound area among the groups except thigh bruising, which developed more frequently in group D. CONCLUSION: The reduced dosage and administration period of VTE prophylactic medicine combined with mechanical prophylaxis for Korean TKA patients showed no fatal PE, but some minor bleeding incidents frequently developed with 7 days of dalteparin injections. We need to adjust the dosage and duration of prophylactic medication deliberately for Korean TKA patients, considering prophylaxis effectiveness and bleeding complication risks.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Artroplastia
/
Embolia Pulmonar
/
Coxa da Perna
/
Aspirina
/
Incidência
/
Dalteparina
/
Artroplastia do Joelho
/
Trombose Venosa
/
Tromboembolia Venosa
/
Hemorragia
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
The Journal of the Korean Orthopaedic Association
Ano de publicação:
2012
Tipo de documento:
Article