Prognostic Significance of Expression of Glutathione S-Transferase-pi and Multidrug Resistance-Associated Protein in Nasopharyngeal Carcinoma / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 791-795, 2002.
Article
em Ko
| WPRIM
| ID: wpr-649585
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: For the treatment of nasopharyngeal carcinoma (NPC), radiation therapy is a primary option. Because of distant metastasis and the high incidence of a locoregional failure following radiotherapy, the combined treatment modality with chemotherapy is applied, although resistance to chemotherapy makes chemotherapy less effective. The Cisplatin-based chemotherapy has been widely used in the field of nasopharyngeal cancer. The Cisplatin resistance is known to be caused by the multidrug resistance-associated protein (MRP), which is one of the drug-export pumps and the glutathione S-transferase (GST)-pi which catalyzes the conjugation of the GSH (glutathione) and the cisplatin. The aim of this study is to determine the predictive value of GST-pi and MRP upon the response to cisplatin in nasopharyngeal carcinoma. SUBJECTS AND METHOD: We analyzed tumor tissues from 49 cases of paraffin block specimens which were diagnosed with NPC and treated at Chonnam National University Hospital. The immunohistochemical study for the GST-pi and the MRP was performed with paraffin block specimens of nasopharyngeal cancers. RESULTS: In the GST-pi, the relationship between the early stage (64.3%) and the advanced stage (91.4%) was statistically significant (p=0.020). The expression of the GST-pi and the MRP had no relationship with the clinical factor, the response to chemotherpy and the survival rate. CONCLUSION: Because the expression of the GST-pi and the MRP in the nasopharyngeal carcinoma could not predict the response to chemotherapy. So the efforts to find the predictive value of the chemotherapy are needed.
Palavras-chave
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Base de dados:
WPRIM
Assunto principal:
Parafina
/
Radioterapia
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Neoplasias Nasofaríngeas
/
Incidência
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Taxa de Sobrevida
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Cisplatino
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Proteínas Associadas à Resistência a Múltiplos Medicamentos
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Tratamento Farmacológico
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Glutationa
/
Glutationa Transferase
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2002
Tipo de documento:
Article