Effects of Estrogen on Intracellular Calcium-Related T-Lymphocyte Function
Tissue Engineering and Regenerative Medicine
; (6): 270-273, 2016.
Article
em En
| WPRIM
| ID: wpr-649689
Biblioteca responsável:
WPRO
ABSTRACT
Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E₂) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E₂ concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E₂. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Hormônios Esteroides Gonadais
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Linfócitos B
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Linfócitos T
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Canais de Cálcio
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Cálcio
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Citocinas
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Fura-2
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Engenharia Tecidual
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Medicina Regenerativa
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Estradiol
Limite:
Humans
Idioma:
En
Revista:
Tissue Engineering and Regenerative Medicine
Ano de publicação:
2016
Tipo de documento:
Article