New Bone Formation Following Transplantation of Stem Cells and Nanoscale Hydroxyapatite Scaffold Materials into Rabbit Long Bone Defects / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
; : 18-27, 2011.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-652667
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
We observed new bone formation following the transplantation of allogenic periosteum-derived stem cells and different sizes of hydroxyapatite (HA) scaffold materials into rabbit long-bone defects. MATERIALS ANDMETHODS:
Thirty-two white rabbits were grouped according to the material transplanted into their tibial bone defects group 1 (microscale HA only); group 2 (nanoscale HA only); group 3 (microscale HA plus stem cells); and group 4 (nanoscale HA plus stem cells). Viscosity was controlled by the relative amounts of HA and agar. After surgery, radiologic, microscopic, and biochemical observations were performed weekly for 8 weeks.RESULTS:
Nanoscale HA (groups 2 and 4) provided better bone formation than microscale HA (groups 1 and 3). The rabbits that had been transplanted with nanoscale HA plus stem cells (group 4) had more homogeneous bone formation during the natural repair process than the other groups.CONCLUSION:
Further study is required using nanoscale HA plus organic substance and stem cells, which are more similar to human bone structure, for better bone formation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Células-Tronco
/
Viscosidade
/
Durapatita
/
Transplantes
/
Ágar
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Orthopaedic Association
Ano de publicação:
2011
Tipo de documento:
Artigo