Quantitative Analysis of Agmatine by HPLC in Ischemic Brain / 대한해부학회지
Korean Journal of Anatomy
; : 257-264, 2003.
Article
em Ko
| WPRIM
| ID: wpr-653803
Biblioteca responsável:
WPRO
ABSTRACT
Agmatine, a widely distributed molecule in mammalian tissues, shows neuroprotective effects in brain ischemia. We describe the neuroprotective effects of agmatine in the mouse MCAO model and the quantitative change of agmatine in ischemic injury. Brain ischemic injured mice were injected with agmatine (100 mg/kg of mouse, IP). Agmatine significantly reduced the infarct area after MCAO. Despite the similar patterns of agmatine change observed in control or agmatine injected animals, the agmatine levels of the penumbra were significantly higher than those of the striatum and the cerebral cortex during the early period (<1 hour after 2 hours of MCA occlusion). This suggests that the early period, during which agmatine levels increase in the brain, is the crucial period in terms of neuroprotective effect during ischemia.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Encéfalo
/
Reperfusão
/
Córtex Cerebral
/
Isquemia Encefálica
/
Cromatografia Líquida de Alta Pressão
/
Fármacos Neuroprotetores
/
Agmatina
/
Isquemia
Limite:
Animals
Idioma:
Ko
Revista:
Korean Journal of Anatomy
Ano de publicação:
2003
Tipo de documento:
Article