Protective Effect of Fibroin BF-7 on Neuronal Cell Death in Alzheimer Model using Amyloid beta Peptide / 대한해부학회지
Korean Journal of Anatomy
; : 57-67, 2007.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-654756
Biblioteca responsável:
WPRO
ABSTRACT
Factors such as senescence,stress and neurodegenerative diseases,including Alzheimer's disease, contribute to the impairment of organs,especially the brain.They also negatively affect normal brain functions such as memory and cognition.In this study,the neuroprotective role of the natural product BF-7 was examined against A beta - induced neurotoxicity in SK-N-SH human neuronal cells.BF-7 significantly attenuated A beta-induced apoptosis as measured by intracellular calcium levels,accumulation of reactive oxygen species,mitochondrial dysfunction,and caspase activity.These results strongly indicate that BF-7 plays an effective and positive role in the improvement of brain functions,including learning and memory,in our model system for Alzheimer's disease.Thus,BF-7 might be useful for developing strategies to protect the nervous system and improve brain function.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Encéfalo
/
Cálcio
/
Peptídeos beta-Amiloides
/
Morte Celular
/
Apoptose
/
Estresse Oxidativo
/
Doença de Alzheimer
/
Fibroínas
/
Amiloide
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Ano de publicação:
2007
Tipo de documento:
Artigo