Effects of different doses of budesonide combined with montelukast on peripheral blood Th17/Treg in children with bronchial asthma / 中国基层医药

ABSTRACT

Objective To study the effects of different doses of budesonide combined with montelukast on peripheral blood Th17/Treg in children with bronchial asthma. Methods 96 children with bronchial asthma were randomly divided into the observation group ( n=48 ) and the control group ( n=48 ) according to the digital table method. The two groups were given conventional treatment of phlegm,anti-inflammatory,oxygen therapy,and so on. The control group was given montelukast 5mg/late, budesonide inhalation 0. 5mg, every 12h, while the observation group was given montelukast 5mg/late, budesonide inhalation 1mg, every 12h. The two groups were treated for 8 weeks. Before and after treatment,the airway responsiveness ( Rrsc) ,nocturnal symptom score,Th17 and Treg cells were evaluated. Results Before treatment, the Rrsc daytime symptom scores, night symptom scores of the control groupwere(4.76±0.51)cmH2O,(2.93±0.47)points,(2.97±0.49)points,respectively,andaftertreatment, thosewere(2.98±0.38)cmH2O,(1.62±0.38)points,(1.69 ± 0.34)points,respectively.Beforetreatment,the Rrsc daytime symptom scores,night symptom scores of the observation group were (4. 73 ± 0. 49)cmH2O,(2. 86 ± 0.41)points,(2.91 ±0.44)points,while after treatment,those were (2.06 ±0.31)cmH2O,(1.01 ±0.29)points, (1. 15 ± 0. 31)points,respectively. After treatment,the airway responsiveness,night symptom scores of the two groups were significantly decreased (t=3. 906,4. 178,3. 006,6. 729,3. 164,4. 096,all P<0. 05),and compared with the control group,those in the observation group were significantly lower (t=2. 328,3. 725,2. 824,all P<0. 05). Before treatment,the peripheral blood Th17,Treg and Th17/Treg in the control group were (2. 95 ± 0. 36)%,(6. 37 ± 1. 09)% and (0. 46 ± 0. 11),respectively,while after treatment,those were (2. 36 ± 0. 31)%,(7. 81 ± 1. 33)% and (0. 30 ± 0. 09),respectively. Before treatment,the peripheral blood Th17,Treg and Th17/Treg in the observation group were (2. 98 ± 0. 41)%,(6. 29 ± 1. 04)% and (0. 47 ± 0. 13),respectively,while after treatment,those were (2. 09 ± 0. 25)%,(8. 32 ± 1. 42)% and (0. 25 ± 0. 06),respectively. After treatment,the peripheral blood Th17 and Th17/Treg in the two groups were significantly decreased (t =2. 136,2. 998,2. 174,3. 806,all P <0. 05),and compared with the control group,which in the observation group were significantly lower ( t=2. 128,2. 476,all P<0. 05). The Treg in peripheral blood of the two groups were increased significantly after treatment (t=3. 092,4. 526, all P<0. 05),and compared with the control group,which in the observation group increased more significantly (t=2. 992,P <0. 05). Conclusion High dose budesonide combined with montelukast can significantly improve the balance of Th17/Treg in children with bronchial asthma,reduce airway responsiveness and clinical symptoms.