Clinical observation of caffeic acid in the treatment of thrombocytopenia (CIT) caused by cancer chemotherapy / 中国肿瘤临床

ABSTRACT

Objective:To evaluate the clinical efficacy and safety of caffeic acid for thrombocytopenia induced by cancer chemothera-py. Methods:A total of 60 patients received the same chemotherapy treatment on cycles 1, 2, and 3. They were given mimetic agent as negative control on the first course. On the second and third cycles, caffeic acid tablets were given from the first day of chemothera-py. Results:The lowest and highest platelet levels of the treatment group during the drug treatment period were significantly higher than those of the negative control group (P<0.001). No significant difference in the period of days of PLT<50×109/L was observed be-tween the groups, although a decreasing trend (P>0.05) was observed. After chemotherapy, the days required for platelet recovery to PLT≥75×109/L and PLT≥100×109/L in the treatment group was significantly fewer than in the negative control group (P<0.001). All the patients did not receive any platelet transfusion during the trial. Conclusion:Caffeic acid tablets were safe and effective for thrombocy-topenia induced by tumor chemotherapy.