Effects of different doses of atorvastatin on lipid lowering in patients with hyperlipidemia and type 2 diabetes mellitus / 药物评价研究

ABSTRACT

Objective To compare the effects of different doses of atorvastatin on lipid lowering in patients with hyperlipidemia and type 2 diabetes mellitus.Methods From January 2014 to December 2016,140 patient with hyperlipidemia and type 2 diabetes mellitus in our hospital for diagnosis and treatment were selected as the research object,all the patients were divided into observation group and control group with 70 cases in each group accorded to randomly.The control group was given low-dose atorvastatin treatment,the observation group was given high-dose atorvastatin treatment,all patients were observed for 4 week.Results The blood glucose and glycated hemoglobin in the observation group and the control group after treatment were significantly lower than that before treatment (P ＜ 0.05),and compared between the two groups were not significant difference compared.The TG,TC and LDL-C in the observation group and the control group after treatment were lower than before treatment,HDL-C was higher than that before treatment (P ＜ 0.05),and the TG,TC,HDL-C and LDL-C in the observation group after treatment were significantly difference compared with the control group (P ＜ 0.05).After treatment,the total efficiency in observation group and the control group were 95.7％ and 97.1％,there was no significant difference compared between the two groups.After treatment followed-up 6 months,the arrhythmia,heart failure,cardiogenic shock and complication rate in the observation group was 8.6％,so that was 27.1％ in the control group,the observation group was significantly less than the control group (P ＜ 0.05).Conclusion Atorvastatin in treatment of hyperlipidemia patients with type 2 diabetes has good effect,especially high-dose atorvastatin has better lipid lowering effect,thereby reduce the follow-up cardiovascular complications,and has very good application value.