Progress of the relationship between angiotensin Ⅱ and its type 1 receptor and some malignant tumors / 肿瘤研究与临床

ABSTRACT

Angiotensin Ⅱ (Ang Ⅱ) is the main effector of the renin-angiotensin system (RAS). As a major regulator of blood pressure and cardiovascular homeostasis, Ang Ⅱis involved in the regulation of cell growth, proliferation and apoptosis. Ang Ⅱtype 1 receptor (AGTR1) is the important part of the RAS by mediating most of the Ang Ⅱ actions. Recently evidence suggested that AGTR1 correlated with tumor angiogenesis and poor patient outcome in cancer. Therefore, AGTR1 blockers have the potential to suppress the tumor angiogenesis and metastasis. This article intents to summarize the progression of the relationship between AngⅡ,AGTR1 and some malignant tumors.