Retrospective analysis of 135 ADR cases of TCMI from 2011 to 2016 in Beijing University of Chinese Medicine Dongfang Hospital / 药物评价研究

ABSTRACT

Objective To learn the adverse drug reaction (ADR) of traditional Chinese medicine injection (TCMI) in Dongfang Hospital of Beijing University of Chinese Medicine (BUCM),to master the characteristics of the occurrences of ADR,and to provide basis for safe and rational clinical drug use.Methods Locating all the reported ADR cases by Dongfang Hospital of BUCM to national ADR monitoring system from June 2011 to May 2016,and make retrospective analysis of them.Results Eighteen kinds of TCMI that caused the total 135 ADR cases,50 out of all the 135 instances were male patients,whilst the rest 85 instances were female patients;The main kinds of TCMI that caused ADR problems were TCMI for relieving heat and toxic material and TCMI for promoting blood circulation to remove blood stasis;TCMI was used jointly with antibiotics and biological product etc.;And the circumstances of ultra-dose and improper infusion allocation existed.The clinical manifestation included many skin lesion cases.All the patients suffered from ADR were cure.Conclusion Prudent and rational use of drugs,standardized clinical use procedure,and clinical re-evaluation are key aspects to lower the incidence rate ofADR of TCMI and to safe and rational use of drugs.