Effects of high-dose methylprednisolone combined with femoral nerve block on pain and recovery after knee replacement / 实用医学杂志

ABSTRACT

Objective To explore the effect of high-dose methylprednisolone combined with femoral nerve block on postoperative analgesia and recovery following total knee arthroplasty(TKA).Methods We performed a randomized,placebo-controlled,double-blind study. 60 patients were divided into a study group(groupMF)and a control group(F group).Patients in group MF received high-dose methylprednisolone combined with femoral nerve block. Patients in group F received equivalent saline combined with femoral nerve block. The rest pain and activi-ties pain,uses of analgesic medication,24 h CRP,time to ambulation,and adverse reactions after operation were recorded.Results There were significant differences in the rest pain and activities pain at hours 6,12,24,and 48,uses of analgesic medication,24 h CRP,time to ambulation and PONV(P < 0.05),group MF was better than group F.There was no significant difference in other adverse reactions(P>0.05).Conclusions High-dose methylprednisolone combined with femoral nerve block can effectively relieve pain and reduce uses of analgesic drugs after TKA,with less systemic inflammatory response and PONV.It is helpful for the early recovery in knee function.