Gut microbiota and non-alcoholic fatty liver disease / 中华临床营养杂志

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) is a common and poorly understood liver disease whose incidence is globally rising.The prevalence of NAFLD is 25％-30％,and its main pathological change is the pathological accumulation of lipids in the liver.At present,research has confirmed that gut microbiota play a crucial role in the development of NAFLD.Gut microbiota may influence the NAFLD pathogenesis by increasing the inflammation in liver,altering the intestinal permeability,and affecting energy and substance matabolisms.This article reviews the roles of gut microbiota in the pathogenesis and treatment of NAFLD.