The effect of single dose of brimonidine-purite 0.15% on choroidal thickness in healthy volunteers / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 2000-2004, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-669202
Biblioteca responsável:
WPRO
ABSTRACT
AIM:
To evaluate the potential posterior segment effects of topical application of brimonidine-purite 0.15% through measurement of choroidal thickness (CT) in healthy eyes using enhanced depth imaging spectraldomain optical coherence tomography (EDI-SD-OCT).METHODS:
Thirty-two eyes of 32 healthy subjects were included in this prospective,placebo controlled interventional clinical trial.They received one drop of topical preservative-free artificial tears as placebo for the first day and one drop of brimonidine-purite 0.15% for the second day.Intraocular pressure,ocular perfusion pressure (OPP),and EDI-SD-OCT were performed at baseline,at 1,3 and 5h after the treatments.RESULTS:
Compared to the measurements obtained at baseline,the CT measurements obtained after the topical application of brimonidine-purite 0.15% significantly increased at the sub-fovea (P=0.001),at temporal 1500 μm to the fovea (P=0.003) and at nasal 1500 μm to the fovea (P=0.003).Choroidal thickness was unchanged in placebo group during the study (P >0.05).There was no significant reduction in the OPP in both groups (P >0.05).There were no adverse events during the study.CONCLUSIONS:
Contrary to expectations,topical administration of brimonidine-purite 0.15% resulted with thickening of sub-foveal,temporal and nasal CT.This might be related to altered auto-regulation mechanisms in choroidal vessels.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio clínico controlado
Idioma:
Chinês
Revista:
International Eye Science
Ano de publicação:
2017
Tipo de documento:
Artigo