Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro / 中西医结合学报
Journal of Integrative Medicine
; (12): 425-38, 2014.
Article
em En
| WPRIM
| ID: wpr-671904
Biblioteca responsável:
WPRO
ABSTRACT
Use of cisplatin, a conventional anticancer drug, is restricted because it generates strong hepatotoxicity by accumulating in liver. Therefore its anticancer potential can only be fully exploited if its own toxicity is considerably reduced. Towards this goal, ethanolic extract of the plant, Boldo (Peumus boldus), known for its antihepatotoxic effects, was used simultaneously with cisplatin, to test its ability to reduce cisplatin's cytotoxicity without affecting its anticancer potential.
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Base de dados:
WPRIM
Idioma:
En
Revista:
Journal of Integrative Medicine
Ano de publicação:
2014
Tipo de documento:
Article