Assessment of co-segregated TLR4 genotypes among Nigerian children with asymptomatic and clinical malaria
Asian Pacific Journal of Tropical Biomedicine
; (12): 96-102, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-673054
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To assess the occurrence and pattern of Toll-like receptor 4 (TLR4) co-segregated genotypes among children with Plasmodium falciparum malaria in Nigeria.Methods:
In this case-control study, a total of 79 Plasmodium falciparum infected children aged 2–7 years and 105 age-matched uninfected controls of Yoruba descents in Lagos were studied. The extracted DNA samples were used for TLR4 genotyping at codons 299 (Asp> Gly) and 399 (Thr >Ile) by PCR-restriction fragment length poly-morphism. Malaria infection was diagnosed by blood smear microscopy and infected children were stratified into asymptomatic, uncomplicated and severe malaria sub-groups. Malnutrition was determined by measuring the mid upper arm circumference and anemia was defined as hemoglobin0.05) in frequency between infected and non-infected children. However, low and high occur-rences of the TLR4 Asp299Asp/Thr399Thr and Asp299Gly/Thr399Thr genotypes were observed in the severe malaria subgroup.Conclusions:
This study reveals a protective role for TLR4 Asp299Gly/Thr399Ile and Asp299Asp/Thr399Thr genotypes against severe malaria in Nigerian children.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Malária
/
Doenças Negligenciadas
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2017
Tipo de documento:
Artigo