Determination of methaqualone and 2-methyl-3[2-(hydroxymethyl) phenyl]-4 (3H)quinazolinone concentrations in human serum by RP-HPLC / 中国法医学杂志
Chinese Journal of Forensic Medicine
; (6)1986.
Article
em Zh
| WPRIM
| ID: wpr-673116
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WPRO
ABSTRACT
Methaqualone and 2-methyl-3 [2- (hydroxymethyl) phenyl]- 4 (3H) quinazolinone (metabolite I) concentrations in human serum wereanalyzed quantitatively by reverse high performance liquid chromatography (RP-HPLC). The concentrations of methaqualone ranging from 1-35?g/ml were in good linear relationship(Correlation coefficient r = 0. 9980, regression line y = 0. 06324x-0. 1029), The average recovery of methaqualone reached as high as 102.08?9. 987(SD)% (n= 5). The detective limit was 1 ng. The relative quantity of metabolite I was determined according to the linear concentration of methaqulone. RP-HPLC assay is proved to be useful in determening blood methaqualone and metabolite I concentrations in forensic toxicology.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Forensic Medicine
Ano de publicação:
1986
Tipo de documento:
Article