CORRELATION BETWEEN IMMUNOFUNCTION AND sIL-2R IN THE NORMAL POPULATION AND MALIGNANCIES / 肿瘤研究与临床

ABSTRACT

Objective:Effect of serum IL 2R on immunofunction were studied.Methods:Serum IL 2R and lymphocytic competence to PHA,IL 2,NK activity,LAK activity,subsets of T lymphocytes and delayed skin supersensitization were tested in four groups,including 30 normal controls,16 athletes,50 patients with lung cancer and 50 malignant lymphomas.The correlation between the tested immunofunction in each group were also studied.Results:In normal population,no correlations were found.Malignancies with high level of sIL 2R were negtively correlated with various immunofunctions,such ascytologic competence to IL 2,NK activity,LAK aitivity and number of CD 3.No significant correlation was found in cytologic competence to PHA and ratio of CD 4 and CD 8.Conclusion:sIL 2R is an important blocking factor for immunofunction,but under the interaction between various cytokines in the immunoregulatory network,its blockege is different with strong or week competence.