Liver transplantation for viral hepatitis and hepatic cancer / 西安交通大学学报(医学版)

ABSTRACT

Orthotopic liver transplantation(OLT) has been performed for 42 years.Survival rates have climbed to as high as 88% at 1-year and operative mortality rates have dropped to as low as 0%.Liver resection should still be considered the first-line treatment for patients with hepatocellular carcinoma(HCC) in non-cirrhotic and resectable livers.Liver transplantation must be the preferred approach for cirrhotic livers.OLT for HCC at a more advanced stage is not indicated.Combination therapy with hepatitis B immune globulin(HBIG) and lamivudine for hepatitis B virus(HBV) patients before and after OLT has been reported a survival benefit as compared to non-HBV recipients.Liver transplantation should not be advocated at the hospitals without primary working conditions.