NUTRITIONAL EVALUATION OF SYNTHETIC OIL Ⅲ. Effect of Synthetic Oil on Body Weight, Liver Weight, Blood and Liver Lipids of Rats During Rehabilitation of Hypercholesterolemia / 营养学报

ABSTRACT

Weanling female rats were fed 12% lard diet supplemented with 2 g cholesterol and 60 mg cholic acid per 100 g diet for 52 days. Blood cholesterol levels were then analyzed for individual rat. Animals were divided into 4 groups according to their blood cholesterol levels and body weights. One group of animals, regarded as negative control, was killed immediately. The other 3 groups were fed 12% level of synthetic oil, lard or soybean oil diet respectively without cholesterol and cholic acid supplementation for 3 weeks. During the 3 weeks of rehabilitation, the following parameters were measured body weight and serum cholesterol levels, every week; food intakes, every other day; high density lipoprotein cholesterol (HDL-C) levels at the beginning and the end of the rehabilitation period; fecal steroids excretion, including neutral and acid steroids from the 2nd to the 4th day of rehabilitation; liver weights, liver fat contents and liver cholesterol levels after animals were killed.The results showed that no significant effects on body weights, serum cholesterol levels, liver weights and liver fat contents of different kinds of dietary fat were observed during the rehabilitation period of hyperch-olesterolemia. But synthetic oil, as well as soybean oil diet caused a lower liver cholesterol levels, and higher levels of both serum HDL-C and fecal neutral steroids.