Study on melatonin nasal absorption / 第二军医大学学报
Article
em Zh
| WPRIM
| ID: wpr-677607
Biblioteca responsável:
WPRO
ABSTRACT
Objective:To research the rule of melatonin nasal absorption.Methods: The stability of melatonin in rat nasal wash was studied, after that the in situ rat nasal recirculation methods were used as experimental animal model to study the rule of melatonin nasal absorption.Results:Melatonin was stable in rat nasal wash, its absorption in nasal cavity accorded with first order kinetic equation. The absorption rate constants did not vary with melatonin concentrations.Conclusion:The mechanism of melatonin nasal absorption is passive diffusion, the average absorption rate constant is 1.054?10 -2 min -1 .
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
1999
Tipo de documento:
Article