Study on the antiplatelet effects of phospholipase C Ⅰ——The effects of PLC on platelet aggregation and adhesion / 中国药理学通报

ABSTRACT

AIM To investigate the antiplatelet effects of phospholipase C (PLC) by studying the effects of PLC on platelet adhesion and aggregation. METHODS Auxiliary agent(-), aspirin (+) and six doses of PLC were administered to anaesthetized rabbit via duodenum. Blood was taken from artery carotis before administration and at 1,2,4 hours after administration. Platelet aggregation rates were determined by turbidmetry. Platelet adhesion rates were tested by glass ball method. RESULTS 100 IUPLC?L -1 and 200 IUPLC?L -1 had no evident effect on rabbit's platelet adhesion rate, 400～ 1 000 IUPLC?L -1 decreased the platelet adhesion rate significantly ( P