Study on Animal Pharmacokinetics of Matrine / 中成药

ABSTRACT

The authors determined the concentration of matrine in rabbit blood plasma with HPLC after it was injected intravenously at constant rate and studied the pharmacokinetics with following five dosage groups of 10,15,20,30 and 60 mg/kg,respectively.As a result,the pharmacokinetics of matrine in rabbit body coincides with two-compartment open model.For 10-30mg/kg dosage groups,the t_(1/2)?,Vc and CLS are similar basically. A direct proportion increase in AUC as dose is increased.The matrine reveals linear elim- ination.For 60 mg/kg dosage group,t_(1/2)? obviously lengthens.AUC increases over pro- portion.The elimination of matrine is nonlinear.