Study on improvement of dissolution rate of Yufengningxin Tablets by technique of super fine crushing / 中成药

ABSTRACT

Objective: To evaluate the affect for quality by crushing technology, The dissolution of Yufengningxin Tablets being prepared by different crushing technology was determined by taking the dissolution of puerarin as test marker. Methods: The Tablets were prepared with the fine powder of Pueraria crude drug which was crushed by normal crusher or super fine crusher. The rotatory basket method was used, the cumulative dissolution percentage was determined by HPLC. Results: Statistics indicated there was a significant difference in dissolution parameter (T 50 ) between super fine crushing powder Tablets and normal fine crushing powder Tablets P